51. Wichita
52. Bakersfield
53. Cleveland
54. Aurora 
55. Anaheim 
56. Honolulu
57. Santa Ana
58. Riverside
59. Corpus Christi 
60. Lexington
61. Henderson
62. Stockton
63. Saint Paul
64. Cincinnati 
65. Saint Louis
66. Pittsburgh
67. Greensboro
68. Lincoln
69. Anchorage
70. Plano
71. Orlando
72. Irvine
73. Newark
74. Durham 
75. Chula Vista

Wichita 

Population: 389,938
State: Kansas
Population Change: +1.98%
Population Density: 2,431 per sq. mi. 
Founded: 1868 

Bakersfield

Population: 384,145 
State: California
Population Change: +10.55%
Population Density: 2,529 per sq. mi. 
Founded: 1873

Cleveland 

Population: 381,009 
State: Ohio 
Population Change: -3.98%
Population Density: 4,956 per sq. mi.
Founded: 1796

Aurora 

Population: 379,278
State: Colorado
Population Change: +16.68%
Population Density: 2,356 per sq. mi. 
Founded: 1891

Anaheim 

Population: 350,365
State: California
Population Change: +4.19%
Population Density: 7,021 per sq. mi.
Founded: 1876

Honolulu

Population: 345,065 
State: Hawaii 
Population Change: +2.32%
Population Density: 5,815 per sq. mi. 
Founded: 1907

Santa Ana

Population: 332,318
State: California 
Population Change: +2.40%
Population Density: 12,333 per sq. mi. 
Founded: 1869

Riverside

Population: 331,360
State: California
Population Change: +9.05%
Population Density: 3,999 per sq. mi. 
Founded: 1883

Corpus Christi 

Population: 326,586
State: Texas
Population Change: +7.00%
Population Density: 1,866 per sq. mi. 
Founded: 1747 

Lexington 

Population: 323,152
State: Kentucky 
Population Change: +9.25%
Population Density: 1,123 per sq. mi. 
Founded: 1782

Henderson

Population: 320,189
State: Nevada
Population Change: +24.23%
Population Density: 2,798 per sq. mi. 
Founded: 1941 

Stockton

Population: 312,697 
State: California
Population Change: +7.20%
Population Density: 4,977 per sq. mi. 
Founded: 1850 

Saint Paul 

Population: 308,096 
State: Minnesota 
Population Change: +8.08%
Population Density: 5,815 per sq. mi. 
Founded: 1854 

Cincinnati

Population: 303,940 
State: Ohio 
Population Change: +2.36%
Population Density: 3,860 per sq. mi. 
Founded: 1788 

Saint Louis

Population: 300,576 
State: Missouri 
Population Change: -5.86%
Population Density: 5,023 per sq. mi. 
Founded: 1764 

Pittsburgh 

Population: 300,286
State: Pennsylvania
Population Change: -1.77%
Population Density: 5,481 per sq. mi. 
Founded: 1758 

Greensboro

Population: 296,710 
State: North Carolina
Population Change: +10.03%
Population Density: 2,237 per sq. mi. 
Founded: 1808

Lincoln 

Population: 289,102
State: Nebraska
Population Change: +11.89%
Population Density: 3,044 per sq. mi.
Founded: 1856

Anchorage

Population: 288,000
State: Alaska
Population Change: -1.31%
Population Density: 175 per sq. mi. 
Founded: 1914

Plano

Population: 287,677 
State: Texas
Population Change: +10.71%
Population Density: 3,990 per sq. mi. 
Founded: 1873

Orlando

Population: 287,442
State: Florida 
Population Change: +20.62%
Population Density: 2,635 per sq. mi. 
Founded: 1843

Irvine

Population: 287,401 
State: California
Population Change: +33.35%
Population Density: 4,057 per sq. mi. 
Founded: 1971 

Newark 

Population: 282,011
State: New Jersey
Population Change: +1.76%
Population Density: 11,691 per sq. mi. 
Founded: 1663

Durham

Population: 278,993
State: North Carolina
Population Change: +22.19%
Population Density: 2,395 per sq. mi. 
Founded: 1869 

Chula Vista 

Population: 274,492 
State: California 
Population Change: +12.54%
Population Density: 5,387 per sq. mi. 
Founded: 1911